| 03/10/2021 18:00 | Use Computer Gross Empoli | Solbat Piombino | 82 - 70 | Palestra Lazzeri - Empoli |
| 10/10/2021 18:00 | 3G Electronics Legnano | Use Computer Gross Empoli | 90 - 68 | PalaBorsani - Castellanza |
| 16/10/2021 21:00 | Use Computer Gross Empoli | All Food-Enic Firenze | 66 - 72 | Palestra Lazzeri - Empoli |
| 23/10/2021 21:00 | Use Computer Gross Empoli | Riso Scotti Pavia | 0 - 0 | Palestra Lazzeri - Empoli |
| 30/10/2021 20:30 | Coelsanus Robur et Fides Varese | Use Computer Gross Empoli | 0 - 0 | C.S. Campus Campo "A" - Varese |
| 06/11/2021 21:00 | Use Computer Gross Empoli | Elachem Vigevano | 0 - 0 | Palestra Lazzeri - Empoli |
| 13/11/2021 21:00 | Mamy.eu Oleggio | Use Computer Gross Empoli | 0 - 0 | Sport Cube - Cameri |
| 20/11/2021 21:00 | Use Computer Gross Empoli | Cipir College Borgomanero | 0 - 0 | Palestra Lazzeri - Empoli |
| 28/11/2021 18:00 | La Patrie San Miniato | Use Computer Gross Empoli | 0 - 0 | Pala Crédit Agricole Italia |
| 04/12/2021 21:00 | Unicusano Pielle Livorno | Use Computer Gross Empoli | 0 - 0 | Amedeo Modigliani Forum - Livorno |
| 08/12/2021 17:00 | Use Computer Gross Empoli | Libertas Livorno 1947 | 0 - 0 | Palestra Lazzeri - Empoli |
| 12/12/2021 18:00 | Sintecnica Cecina | Use Computer Gross Empoli | 0 - 0 | Palasport " Franco Poggetti" |
| 18/12/2021 21:00 | Use Computer Gross Empoli | Paffoni Fulgor Omegna | 0 - 0 | Palestra Lazzeri - Empoli |
| 09/01/2022 18:00 | S.Bernardo-Abet Langhe Roero | Use Computer Gross Empoli | 0 - 0 | Pala 958 Santero - Corneliano d'Alba |
| 16/01/2022 18:00 | Use Computer Gross Empoli | LTC Group Sangiorgese Basket | 0 - 0 | Palestra Lazzeri - Empoli |
| 23/01/2022 18:00 | Solbat Piombino | Use Computer Gross Empoli | 0 - 0 | Palatenda - Piombino |
| 29/01/2022 21:00 | Use Computer Gross Empoli | 3G Electronics Legnano | 0 - 0 | Palestra Lazzeri - Empoli |
| 05/02/2022 18:30 | All Food-Enic Firenze | Use Computer Gross Empoli | 0 - 0 | Palacoverciano - Firenze |
| 13/02/2022 18:00 | Riso Scotti Pavia | Use Computer Gross Empoli | 0 - 0 | PalaRavizza - Pavia |
| 19/02/2022 21:00 | Use Computer Gross Empoli | Coelsanus Robur et Fides Varese | 0 - 0 | Palestra Lazzeri - Empoli |
| 27/02/2022 18:00 | Elachem Vigevano | Use Computer Gross Empoli | 0 - 0 | PalaBasletta - Vigevano |
| 05/03/2022 21:00 | Use Computer Gross Empoli | Mamy.eu Oleggio | 0 - 0 | Palestra Lazzeri - Empoli |
| 20/03/2022 18:00 | Cipir College Borgomanero | Use Computer Gross Empoli | 0 - 0 | Pala Don Bosco - Borgomanero |
| 26/03/2022 21:00 | Use Computer Gross Empoli | La Patrie San Miniato | 0 - 0 | Palestra Lazzeri - Empoli |
| 02/04/2022 21:00 | Use Computer Gross Empoli | Unicusano Pielle Livorno | 0 - 0 | Palestra Lazzeri - Empoli |
| 10/04/2022 18:00 | Libertas Livorno 1947 | Use Computer Gross Empoli | 0 - 0 | Amedeo Modigliani Forum - Livorno |
| 16/04/2022 21:00 | Use Computer Gross Empoli | Sintecnica Cecina | 0 - 0 | Palestra Lazzeri - Empoli |
| 23/04/2022 21:00 | Paffoni Fulgor Omegna | Use Computer Gross Empoli | 0 - 0 | PalaBattisti - Verbania |
| 30/04/2022 21:00 | Use Computer Gross Empoli | S.Bernardo-Abet Langhe Roero | 0 - 0 | Palestra Lazzeri - Empoli |
| 08/05/2022 18:00 | LTC Group Sangiorgese Basket | Use Computer Gross Empoli | 0 - 0 | PalaBertelli - San Giorgio su Legnano |
