| 27/09/2026 18:00 | Mens Sana Basketball Siena | Basketball Club Lucca | 0 - 0 | PalaEstra |
| 04/10/2026 18:00 | OraSì Ravenna | Mens Sana Basketball Siena | 0 - 0 | PalaCosta - Ravenna |
| 11/10/2026 18:00 | Mens Sana Basketball Siena | Luiss Roma | 0 - 0 | PalaEstra |
| 18/10/2026 18:00 | Consorzio Leonardo Dany Quarrata | Mens Sana Basketball Siena | 0 - 0 | PalaCarrara - Pistoia |
| 25/10/2026 18:00 | Mens Sana Basketball Siena | Solbat Golfo Piombino | 0 - 0 | PalaEstra |
| 01/11/2026 18:00 | PSA Napoli Est | Mens Sana Basketball Siena | 0 - 0 | PalaDennerlein - Napoli |
| 08/11/2026 18:00 | Mens Sana Basketball Siena | Allianz Pazienza Cestistica San Severo | 0 - 0 | PalaEstra |
| 11/11/2026 20:30 | Consultinvest Loreto Pesaro | Mens Sana Basketball Siena | 0 - 0 | Pala MegaBox - Pesaro |
| 15/11/2026 18:00 | Mens Sana Basketball Siena | Ristopro Fabriano | 0 - 0 | PalaEstra |
| 22/11/2026 18:00 | Liofilchem Roseto | Mens Sana Basketball Siena | 0 - 0 | PalaMaggetti - Roseto degli Abruzzi |
| 29/11/2026 18:00 | Mens Sana Basketball Siena | Fabo Herons Montecatini | 0 - 0 | PalaEstra |
| 06/12/2026 18:00 | Benacquista Assicurazioni Latina | Mens Sana Basketball Siena | 0 - 0 | Palasport – Cisterna di Latina |
| 13/12/2026 18:00 | Mens Sana Basketball Siena | Virtus GVM Roma 1960 | 0 - 0 | PalaEstra |
| 16/12/2026 20:30 | Felice Scandone Avellino | Mens Sana Basketball Siena | 0 - 0 | Pala Del Mauro - Avellino |
| 20/12/2026 18:00 | Mens Sana Basketball Siena | Pielle Livorno | 0 - 0 | PalaEstra |
| 30/12/2026 20:30 | Mens Sana Basketball Siena | Umana San Giobbe Chiusi | 0 - 0 | PalaEstra |
| 03/01/2027 18:00 | Tema Sinergie Faenza | Mens Sana Basketball Siena | 0 - 0 | PalaCattani - Faenza |
| 10/01/2027 18:00 | Mens Sana Basketball Siena | Consultinvest Loreto Pesaro | 0 - 0 | PalaEstra |
| 17/01/2027 18:00 | Ristopro Fabriano | Mens Sana Basketball Siena | 0 - 0 | PalaChemiba - Cerreto d |
| 20/01/2027 20:30 | Mens Sana Basketball Siena | Consorzio Leonardo Dany Quarrata | 0 - 0 | PalaEstra |
| 24/01/2027 18:00 | Allianz Pazienza Cestistica San Severo | Mens Sana Basketball Siena | 0 - 0 | Palasport "Falcone e Borsellino" - San Severo |
| 31/01/2027 18:00 | Fabo Herons Montecatini | Mens Sana Basketball Siena | 0 - 0 | PalaTerme - Montecatini Terme |
| 07/02/2027 18:00 | Mens Sana Basketball Siena | PSA Napoli Est | 0 - 0 | PalaEstra |
| 14/02/2027 18:00 | Pielle Livorno | Mens Sana Basketball Siena | 0 - 0 | PalaMacchia - Livorno |
| 21/02/2027 18:00 | Virtus GVM Roma 1960 | Mens Sana Basketball Siena | 0 - 0 | Palazzetto dello Sport - Roma |
| 28/02/2027 18:00 | Mens Sana Basketball Siena | Liofilchem Roseto | 0 - 0 | PalaEstra |
| 07/03/2027 18:00 | Umana San Giobbe Chiusi | Mens Sana Basketball Siena | 0 - 0 | PalaPania - Chiusi |
| 21/03/2027 18:00 | Mens Sana Basketball Siena | Benacquista Assicurazioni Latina | 0 - 0 | PalaEstra |
| 27/03/2027 20:30 | Basketball Club Lucca | Mens Sana Basketball Siena | 0 - 0 | PalaTagliate - Lucca |
| 04/04/2027 18:00 | Mens Sana Basketball Siena | OraSì Ravenna | 0 - 0 | PalaEstra |
| 07/04/2027 20:30 | Luiss Roma | Mens Sana Basketball Siena | 0 - 0 | Palazzetto dello Sport - Roma |
| 11/04/2027 18:00 | Mens Sana Basketball Siena | Felice Scandone Avellino | 0 - 0 | PalaEstra |
| 18/04/2027 18:00 | Solbat Golfo Piombino | Mens Sana Basketball Siena | 0 - 0 | Palasport Tenda Piombino |
| 25/04/2027 18:00 | Mens Sana Basketball Siena | Tema Sinergie Faenza | 0 - 0 | PalaEstra |
